BOC Sciences

There are many microorganisms in the world, and these microorganisms play a very important role in human life.  At present, the most extensive application field of microorganisms is pharmaceuticals. With the help of the microbial fermentation , many drugs that are beneficial to human health can be produced.   The history of using fermentation of microorganisms to make medicine can be traced back to 1796, when British doctor E. Jenner used vaccinia vaccination to prevent smallpox and succeeded. By the end of the 19th century, L. Pasteur. P.Enrich and Von Rehiring have successively invented vaccines and toxoids to prevent or treat various bacterial infectious diseases. Since then, research on the use of microorganisms to produce vaccines has developed vigorously. In 1928, Fleming discovered penicillin by accident, but people believed that the results of animal experiments could not guide human medical practice. At the beginning of World War II, with the deepening of people's und...

Human endogenous metabolic compounds are some of the metabolites  produced and found in the human body. The role of these metabolites cannot be underestimated.  And this article will mainly introduce its application in disease diagnosis and drug discovery.   1  Endogenous metabolites can be used for disease diagnosis Diseases lead to changes in the body's pathophysiological processes, and ultimately lead to corresponding changes in metabolites.  Metabolomics is a newly developed discipline following genomics and proteomics. It searches for disease biomarkers through qualitative and quantitative analysis of small molecular metabolites with a relative molecular weight of less than 1,000 in a certain organism or cell. Metabolomics provides a better method of disease diagnosis. In the field of cancer research, methods for diagnosing malignant tumors, screening drugs, and evaluating drug toxicity by observing the abnormal changes of related small molecule metabolism ...

For a long time, chemotherapy has been one of the main treatment options for cancer treatment . However, due to its poor specificity for tumor cells/tissues, chemotherapy is usually associated with a lower treatment window. The antibody-drug conjugate (ADC) technology may provide a potential new therapeutic solution for cancer treatment.   A ntibody-drug C onjugate   (ADC)  refers to an antibody connected to a small molecule payload with a cell-killing effect through a chemical linker.  After encountering a tumor cell, the ADC will bind to the protein on the surface of the tumor cell. Through chemical, enzymatic, or biological processes, the ADC linker  is torn apart and releases a small molecule payload, which then kills tumor cells. This therapy is conceived to deliver cancer-killing drugs specifically to cancer cells like a missile, while protecting healthy cells from harm.   ADC is a complex entity that combines the characteristics of biological drugs a...